Wide receiver Dez Bryant (foot) and cornerback Mo Claiborne (hamstring) have been ruled out of Sunday's game against the Buffalo Bills, the Cowboys announced Saturday.
Bryant was listed as "doubtful" and Claiborne was "questionable" on Friday's injury report. Neither player was able to practice during the week, and they did not make the trip with the team to Buffalo.
Claiborne will miss his second straight game. He also missed two games in November with hamstring and ankle injuries.
Bryant will miss his sixth game of the season. The star receiver missed five straight games earlier this year following surgery to repair the fifth metatarsal in his right foot. He has started eight straight games but has been dealing with nagging foot and ankle injuries the last few weeks.
Cowboys wide receiver Cole Beasley (knee/illness) is also at less than full strength this week – he's listed as "questionable" for Sunday's game after missing two of three practices.